Yale Researchers Find More Genes in Human Genome
NEW HAVEN, Conn.
A study by Yale University researchers provides preliminary evidence that there may be more than twice as many genes in the human genome than previously predicted. Using an advanced genomic technique, researchers looked for all the genes on human chromosome 22. This is the next and necessary step in analyzing and understanding the human genome.
“These are very promising findings,” says first author John Rinn, a fourth-year graduate student in a molecular, cellular and developmental biology at Yale. “We found that many of the known, related and predicted genes were verified to be expressed in the cell. More importantly, our study reveals twice as many transcribed bases than have been reported previously, potentially indicating that there are twice as many genes in the human genome.”
Rinn and his collaborators mapped all the coding regions — spots where genes are potentially located — of chromosome 22 using an advanced microarray technology. They found that a DNA microarray representing nearly all of the unique sequences of human chromosome 22 was constructed and used to measure global transcriptional activity in a complex tissue similar to the placenta.
